Abstract
Summary
The following substances and procedures have been observed to have effects on the rate of temperature rise in chilled rabbits confined to an erect position (1) indicative of tendency to produce impairment in ability to counteract gravitational interference with circulation: blood loss, decreased salt intake, “softening” inaction, infection, sodium nitrite, and, to a considerably less marked extent, sulfanilamide; and (2) indicative of tendency to produce a converse lessening of pre-existing impairment: paredrine, ephedrine, coramine, ascorbic acid, thyroid, and hardening. Paredrine had a parallel effect vs. nitrite-induced impairment. Coramine, effective vs. spontaneous impairment, appeared to be ineffective vs. nitrite-induced impairment, d-Amphetamine, in direct contrast, gave indications of effectiveness vs. nitrite-induced impairment but not vs. spontaneous impairment. Impairment as a result of blood loss was substantially lessened following intravenous sodium ascorbate, in massive dosage.
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