Comparative Effects on Experimental Tuberculosis of 2,4′-Dichloro-benzophenone and 4,4′-Diaminodiphenylsulfone.

Abstract

Summary and conclusions

The effect of 2,4′-dichlorobenzophenone on experimental tuberculosis of guinea pigs was studied. Although 4,4′-diaminodiphenylsulfone was capable of exerting an impressive inhibitory effect, the chlorine derivative of benzophenone did not retard or influence favorably the course or character of the disease as exemplified among the animals in the untreated or control group. The following conclusions are drawn: 1. Favorable bacteriostatic results in vitro of chemical compounds against tubercle bacilli are not necessarily indicative of favorable results in experiments in vivo. 2. 4,4′-diaminodiphenylsulfone under the conditions imposed proved capable of combating a tuberculous infection rather satisfactorily. 3. The one chlorine derivative of benzophenone studied proved ineffective in altering the expected course of the disease.