Hair Loss in Male Dogs Fed Stilbestrol.

Abstract

Failure of regeneration and loss of hair have been reported 1 in dogs given estradiol benzoate. No account has been found of the same phenomenon in dogs which received synthetic estrogens.

In a recent experiment∗ 4 male dogs received by mouth diethylstilbestroi† 5 mg tablets, over a period of several months. These animals and 2 other male dogs (serving as controls) were also injected subfascially with methylcholanthrene, the changes resulting from which will be described elsewhere. All of the animals were mongrels about 1½ to 3 years old at the start of the experiment. The weights ranged between 15 and 27 lb. and did not vary significantly.

The first dog received 330 mg of stilbestrol in 20 doses of 5 mg, 19 of 10 mg and 2 of 20 mg in a period of 129 days, at the end of which the hair was missing from the right flank.

The second dog received 1790 mg of stilbestrol in 20 doses of S mg and 169 of 10 mg in a period of 292 days, at the end of which the hair was generally thinned, was largely missing from the abdomen and penis, and had failed to regenerate on the forelegs at areas clipped for vein puncture.

The third dog received 1850 mg of stilbestrol in 185 doses of 10 mg in a period of 280 days, at the end of which the hair was missing from the thighs, buttocks, perineum, abdomen, face, and the ventral surface of the tail, thorax, and neck.

The fourth dog received 2985 mg of stilbestrol in 100 doses of 10 mg, 6 of 15 mg, 6 of 20 mg, and 71 of 25 mg in a period of 291 days, at the end of which the hair was absent from the base of the tail, the lumbar regions, the scapular regions, the abdomen