Excretion of Androgens,17 Ketosteroids and Estrogens in the Dog Following Administration of Androgens. ∗

Abstract

Discussion and Summary

In contradistinction to the human, urine androgens do not increase in the dog following administration of androgenic hormones. These findings confirm earlier observations by Kockakian. 6 Administration of androgens also fails to increase the excretion of 17 ketosteroids. However, contrary to earlier findings by Kochakian, 7 dogs were found to excrete estrogens following administration of androgens, as has been found in humans. 1 , 2 , 4 5 This excreted estrogen may be either formed from the administered androgen or may be the result of stimulation of some source of estrogen production. The fact that estrogens are excreted in the castrated and in the adrenalectomized dog following testosterone treatment narrows considerably the possible sources of the estrogens. Conversion from the administered androgen seems more likely but is not yet definitely proven.