Abstract
Summary
The difficulty involved in the study of fox encephalitis because of the highly variable susceptibility of experimental animals to fatal infection has been overcome by the use of methods that produce demonstrable, although not always fatal, infection. Instillation of the virus in the anterior chamber of the eye leads to infection of the eye while intramuscular or subcutaneous injection leads to infection in the regional lymph nodes. Extensive studies on the intraocular method have revealed that it is so uniformly sensitive that accurate virus titrations and neutralization tests can be made. A positive result is manifested by the development of opacity in the cornea, which can be observed grossly and is readily confirmed by the simple technic of demonstrating characteristic inclusion bodies in smears prepared with scrapings from the inner surface of the cornea.
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