Abstract
Summary
1. A suspension of sulfonamides injected subcutaneously into the inguinal region of mice produced high sustained concentrations of the drug in the blood. 2. A single dose of a suspension of sulfathiazole or sulfadiazine injected immediately following inoculation with Cl. welchii protected 45-53% of the mice. A 1 mg dose gave as much protection as a 50 mg dose. A delay in therapy of 1 or 2 hours markedly reduced the protective action. Sulfanilamide gave very little protection.
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