Abstract
Summary
1. Neo-synephrine base is soluble in peanut oil containing oleic acid. 2. Neo-synephrine in oil injected subcutaneously or intramuscularly brings about a more sustained rise in blood pressure than does a similar injection of an equivalent amount of aqueous neo-synephrine HCl. 3. The threshold dose for both forms of neo-synephrine is about 0.05 mg/kg in the dog. Maximal responses are usually obtained with doses of 0.5 mg/kg by either subcutaneous or intramuscular injection. The latter dosage level is not well tolerated and is frequently followed by undesirable side reactions. 4. Neo-synephrine in oil is 28% less toxic than the aqueous neo-synephrine HCl equivalent. The slower rate of absorption from oil is the probable cause for the lower toxicity.
Get full access to this article
View all access options for this article.