Abstract
In the course of more elaborate study of the toxicity of mononitroparaffins and related compounds from the standpoint of industrial hygiene, 1 each substance was also examined for its effect on the blood pressure and respiration of rabbits. The first 6 members of the mononitroparaffin series, i.e., nitromethane, nitroethane, 1- and 2-nitropropane, 1- and 2- nitrobutane, and 2-nitro-2-methyl-propanol, 2-nitro-2-methyl-,3-propanediol, tris-(hydroxymethyl) nitromethane, 2-amino-2-methyl-l-propanol, 2-amino-2-methyl-1,3-propanediol and tris-(hydroxymethyl)methylamine (the last three as hydrochlorides) failed to show any significant effect on either blood pressure or respiration. The same results were obtained in cats with the 6 nitroparaffins by W. Deichmann of this laboratory.
In addition, the effects of nitroethane and 2-nitropropane on the blood pressure of rabbits were compared with those induced by glycerol trinitrate, erythrityl tetranitrate and sodium nitrite. The results are shown in Fig. 1. The nitrates and sodium nitrite had very much more effect in much smaller doses than did the nitroparaffins.
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