Abstract
Summary
Intradermally in guinea pigs the hydrochlorides of 9 new dialkylaminomethyl phenyl p-aminobenzoates were found to produce local anesthesia in 1.0% and 0.5% solution but all caused tissue damage at the site of injection. In 1.0% solution certain of these derivatives abolished the corneal reflex after instillation in rabbit eyes. The hydrochloride of (2-piperidinomethyl-) 4,6-dimethylphenyl p-aminobenzoate (IX) was less toxic subcutaneously in mice and exhibited greater topical activity in rabbits than cocaine hydrochloride but practical application of the anesthetic action of IX or any of the new compounds is complicated by their instability in aqueous solution.
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