Action of Bacterial Toxins on Tumors. IV. Distribution of Tumor-Hemorrhage Agents Among Bacterial Species. ∗

Abstract

Conclusions

An extension was made of an earlier survey of bacterial substances inducing hemorrhage in implanted mouse tumors. It was found that with a few exceptions gram-negative forms induced tumor-hemorrhage, while this property, with one exception, was lacking in the gram-positives. An interesting example was the induction of hemorrhage by the photosynthetic gram-negative purple bacterium Rhodospirillum rubrum. It is concluded that toxins inducing tumor-hemorrhage, and probably bound up in the complex O antigens, are characteristic of gram-negative bacteria.