Abstract
Summary
The effects of adrenal cortical and thyroid substances were studied on the water exchange and related phenomena in hypophysectomized rats during periods after the initial high postoperative d. i. had subsided. 1. Desoxycorticosterone acetate in 1 mg daily doses elevated water exchange, but not to levels characteristic of d. i., whereas whole extract of the adrenal cortex was without effect. 2. Thyroid-feeding in doses that restored oxygen consumption at least to normal elevated the water intake slightly but not the urine output. There was an associated rise in urine specific gravity. The diuretic effects of thyroid hormone under other circumstances in the rat must depend upon the presence of an anterior pituitary. 3. Non-toxic doses of thyroxin, although affecting oxygen consumption, had no effect on water exchange. 4. When desoxycorticosterone and the larger doses of thyroid were given in combination, the toxicity of the latter was overcome. Water intake was doubled, but urine volume did not increase proportionately due to the opposing action of the thyroid substance.
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