Abstract
Summary
Pregnenolone is capable of maintaining spermatogenesis for at least 20 days following hypophysectomy. However, this steroid does not influence the seminal vesicles, since the loss in seminal vesicle weight simulates that observed in the hypophysectomized control. Pregnenolone therefore appears to be gametogenic in action.
A single injection (10 mg) of pregnenolone did not influence uterine weight or the adrenal X-zone of the spayed mouse.
Pregneninolone, which has been shown to exhibit androgenic activity, failed to maintain spermatogenesis in the hypophysectomized rat.
Get full access to this article
View all access options for this article.