Abstract
Summary
Rats receiving purified diets plus sulfaguanidine and succinylsulfathiazole showed a decrease in the number of E. coli in the feces and cecum within three days after the drug was given. The number remained low for 10 days and then began to increase and at the end of the five weeks approached the normal level.
The “total” counts remained constant throughout the test period. Enterococci replaced the coliforms during the time of repressed E. coli growth.
On a succinylsulfathiazole-containing diet supplemented with either liver extract or a crude folic acid concentrate normal growth was maintained in spite of a marked reduction in the number of E. coli in the cecum.
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