Abstract
Summary
Prolonged contact of crystalline androsterone and dehydroisandrosterone with alcohol results in an enhanced biological response as compared with the response obtained from oily solutions of these androgens, when tested by the chick-comb-weigh't method. When these androgens are applied to the combs immediately after going into alcoholic solution, such an enhancement does not occur. Recovery of the crystals from alcoholic solution, after 6 days contact, and subsequent solution in oil gives an altered biological response indicating a possible change in the character of the original materials. These observations suggest that an inert vehicle, such as sesame oil, is to be preferred to alcohol as a vehicle in assaying such androgens.
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