Sulfanilamide Activity Against Escherichia coli Under Anaerobic Conditions. ∗

Abstract

Conclusions

The results of this study show that SA inhibits the respiration and growth of Esch. coli in a synthetic medium with glucose as the source of energy under either aerobic or anaerobic conditions and that PAB also exerts its anti-SA activity under anaerobic conditions. Growth and respiration are inhibited to somewhat the same extent as previously reported by Sevag⁸ for Streptococcus pyogenes and Type I Diplococcus pzeumonice. SA appears to inhibit respiration somewhere between the original dehydrogenase system and the final H-acceptor, possibly inhibiting a H-carrier system as well as the decarboxylase system. It is not evident whether the decreased rate of respiration is due to inhibition of growth or vice versa although Wyss⁹ reports that respiration is inhibited by isomers of SA which do not exhibit “chemotherapeutic activity.”