Abstract
Conclusions
Administration of concen-trated NaCl solutions causes generalized tissue edema and nephrosclerosis in young chicks. Desoxycorticosterone acetate (D.C.A.) exerts a similar effect even on a normal salt intake and sensitizes chicks to the action of sub-threshold concentrations of NaCl. Among a number of steroid preparations tested for this effect only progesterone was found to possess this activity and even this compound was not quite as active as D.C.A.
The expenses of this investigation were defrayed through a grant reeeived from the DesBergers-Bismol Laboratories of Montreal, Canada. We are greatly indebted to Dr. Envin Sclnvenk of the Schering Corporation of Bloomfield, N.J., for all steroid compounds except the pregnanedione which was supplied by Professor E. D. H. Heard and the A16-pregnenedione donated by Dr. O. Kamm of Parke, Davis and Companv. Our thanks are also due to Dr. S. S,. Munro of tlie Canadian Department of Agriculture who furnished the chicks for these experiments.
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