Abstract
Summary
Crude or highly purified preparations known to be very rich in hyaluronidase, such as extracts from rattlesnake venom, leech tissues, and testicle, have a very pronounced effect in dispersing the follicular cells surrounding the ova of mice. It appears very probable that hyaluronidase itself, which plays such an important part in infection, is also responsible for this effect, an indispensable step in fertilization. Final conclusions cannot be reached until the enzyme is obtained in pure state.
P.S. When the manuscript of this paper was ready for publication McClean and Rowlands 4 reported the results of experiments similar to ours but carried out on rat ova and reached the same conclusions as we have.
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