Effect of Posterior Pituitary Extract on Water Up-Take in Frogs After Hypophysectomy and Infundibular Lesions. ∗ †

Abstract

Summary

The effect of posterior pituitary principles on the water up-take in hypophysec-tomized frogs is lower than in the normal. This applies not only to totally hypophysec-tomized frogs but also to those in which only the anterior or the posterior lobe is removed.

After a wide lesion at the base of the third ventricle, the response to posterior pituitary principles falls off very sharply. When the third ventricle is merely punctured in the midline, the response decreases somewhat but not to the same extent as in the case of a wide lesion. A wide lesion at the base of the third ventricle results in a reduction of the same magnitude in response to posterior pituitary principles as does hypophysectomy.