Abstract
The finding that pedicle grafts of jejunum implanted in the wall of the stomach have a profound effect on gastric secretion 1 2 3 leads obviously to an investigation of the effects of similar grafts from other portions of the intestinal tract. We wish to report herewith the results of such grafts on the pH of the gastric mucosa.
Methods. Medium sized mongrel dogs of both sexes were used in these experiments and the following routine employed. A laparotomy was performed and the pH of the gastric mucosa of 7 different regions of the stomach measured by inserting the electrodes of the Beckman pH meter through a gastrotomy. Immediately thereafter a portion of the anterior gastric wall approximately 4 cm x 6 cm was excised and the defect closed by inserting a pedicle graft of intestine. In 4 animals the graft was taken from the duodenum, in 5 from the jejunum, in 3 from the ileum and in 3 from the transverse colon. The graft in each instance consisted of a segment of bowel about 6 cm in length, opened along the antemesenteric border, and with its blood supply intact.
Following this operation the pH of the mucosa was again measured through a gastrotomy at varying intervals.
Results. Transplants from the ileum and colon are without effect so far as influencing the pH of the gastric mucosa after histamine is concerned. On the other hand, with both the duodenal and jejunal grafts the pH of the mucosa rose after the administration of histamine. In the present series the jejunal grafts were somewhat more effective than the duodenal.
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