Abstract
Summary
When gramicidin or tyrocidine in minimal effective amounts is added to suspensions of washed sheep erythrocytes, the rate of hemolysis is much more rapid with tyrocidine than with gramicidin but the latter, a!though slower in action, ultimately causes a greater degree of hemolysis than the former.
Comparative experiments have been done to determine the influence of horse serum on the rate and amount of hemolysis caused by gramicidin and tyrocidine. The hemolytic activity of both substances is decreased in the presence of only 1% of horse serum. Five percent of serum causes further inhibition of the hemolytic activity of gramicidin and completely prevents hemolysis by tyrocidine. Increasing the amount of serum beyond 5% did not result in a further decrease of the hemolytic activity of gramicidin.
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