Abstract
Summary
The addition of pure gamma globulin to normal blood serum produced a positive serum colloidal gold reaction. The purified fraction containing alpha and beta globulins produced no effect. Albumin inhibited the serum colloidal gold reaction. Since the most characteristic and consistent alteration of the serum proteins in liver disease is a decrease in serum albumin and a relatively large increase in gamma globulin it is suggested that the mechanism of the colloidal gold reaction in liver disease depends upon a relative increase in the gamma globulin of the blood.
The author wishes to express his gratitude to Dr. Edwin J. Colin for supplying the purified protein fractions used in this study, which were prepared under contract with the Office of Scientific Research and Development upon reconimendation by the Committee on Medical Research.
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