The Proteus X Bacilli and the Weil-Felix Reaction

Abstract

Summary

It is possible to reduce materially the time necessary to produce in the rat a fully, developed syndrome of biotin deficiency by feeding a diet containing in addition to 15% dried egg-white and 15% casein, 2% dried liver. On this diet most of the signs develop within less than 4 weeks. Biotin depleted animals fed small doses of biotin curatively showed a characteristic, symmetrical lateral graying of the pelage that persisted to some extent even following 5 weeks of biotin supplementation.