Abstract
Recent interest in the direct application of sulfonamide crystals to wound surfaces and to body cavities has stimulated research on the effect of such treatment upon cells cultivated in vitro. 1 , 2 In spite of the higher resistance of embryonic cells in tissue cultures to the action of inhibitory agents, workers in this field hold that in vitro experiments offer stringent and easily controlled conditions for the analysis of drug toxicity.
In addition to the sulfonamides, a new class of compounds characterized by high bactericidal action is being derived from microörganisms. Of these, tyrothricin and its derivatives, are described as unsafe at present for general use, especially when brought in direct contact with the blood stream. 3 , 4 Tyrothricin, however, has been found not to interfere with the healing of wounds 3 and therefore may become useful in this direction.
Get full access to this article
View all access options for this article.