Use of Mice in Testing of Antigenic Power of Tetanus Toxoid

Abstract

Summary

Swiss mice can be used as test animals in place of guinea pigs for the determination of the antigenic power of tetanus toxoid. The advantage in the use of mice lies in two fa%: (1) the immunization period necessary is only 3 weeks instead of the usual 6 weeks; (2) lower cost of mice permits the use of a larger number of animals and animals of greater uniformity than guinea pigs, which contributes to a greater statistical significance and accuracy of the test.