Abstract
Summary
The daily injection of 40 to 80 crop gland units of pituitary lactogenic hormone for 4 to 6 days into rats suckling their young induced secretory changes in a transplanted mammary adenocarcinoma. The hormone produced no effect on the tumors of non-nursing females or normal males. Progesterone also exerted no influence, nor did it affect, when given simultaneously with estradiol dipropionate, the secretory phenomena induced in the neoplastic cells by the latter substance alone. Pituitary lactogenic hormone failed to induce secretion in the tumor cells of animals previously treated with progesterone, and did not enhance the alterations produced by the combined administration of progesterone and estradiol.
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