Abstract
Summary
Single doses of the sodium salts of sulfapyridine and sulfathiazole cause a marked rise in the blood pH which is greatest in the case of sulfapyridine when they are given by intraperitoneal injection. This rise does not occur when they are administered orally even when the observation period is doubled and the blood level of the drug has risen somewhat higher, though it is markedly lower than the level observed three hours after intraperitoneal injection.
Sodium sulfadiazine, on the other hand, does not have this marked effect upon blood pH when administered intraperitoneally or orally even though the blood level is more than twice that observed in either of the other preparations.
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