Abstract
Conclusions
The Armstrong mouse-adapted poliomyelitis strain was successfully passed serially through 16 Syrian hamster brain passages. The disease in hamsters is usually characterized by paralysis of one or two limbs and followed by death. A small number of paralyzed hamsters survived, but developed atrophy and contractures of the affected muscles. The pathology in the infected hamsters is typical of poliomyelitis. The hamster strain is infectious for mice. Human convalescent poliomyelitis serum neutralized the hamster strain. Hamster convalescent serum neutralized the hamster strain as well as the mouse strain. The hamster strain inoculated intracerebrally into 4 monkeys produced no paralysis. Three monkeys, subsequently tested with virulent monkey cord virus, proved to be immune.
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