Abstract
Summary
(1) 0.0025 mg of sulfadiazine is sufficient to protect mice against from 10 to 10,000 50% lethal doses of a virulent strain of Group I meninogococcus. (2) The protective action of sulfadiazine is not inhibited by a single administration of para-aminobenzoic acid accompanying the sulfadiazine, nor by a second injection after 30 min. (3) The protective action of sulfadiazine may be inhibited by repeated subcutaneous injections of para-aminobenzoic acid at 3-hr intervals.
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