Abstract
Summary
Peripheral intravenous injection of 1-dopa was found to produce a marked rise in blood pressure in cats with experimental hypertension; no rise was produced in cats with acute renal ischemia or in normal cats. Intravenous injection of 1-dopa in humans with essential hypertension produced a similar pressor response; a much less marked pressor effect was obtained in humans with normal blood pressure. The possibility is discussed of defective renal deaminization due to kidney ischemia as being responsible for the marked pressor response to 1-dopa injections in essential human hypertension.
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