Abstract
Conclusions
1. Lymph obtained from a traumatized extremity contained a substance which produced an increase in capillary permeability when injected into another dog. 2. When tested upon the dog from which the lymph was obtained, there was evidence that a toxic substance, capable of causing an increase in capillary permeability, appeared after mechanical or thermal trauma. 3. Arterial and venous serum and plasma contained a factor which increased the capillary permeability when injected intracutaneously into other dogs but not when injected into the dog from which the blood had been obtained. 4. It is likely that the presence in the lymph of a substance capable of producing an increase in capillary permeability is dependent upon the appearance, after trauma, of blood plasma in the lymph draining from the extremity.
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