Abstract
Summary
1. Intravenous administration of the protamine, salmine sulfate, to untreated guinea pigs and rats produced death at dose levels of 6-12 mg/100 g. Intraperitoneal injection delayed these effects. 2. The addition of salmine sulfate to whole blood or plasma resulted in the formation of a flocculent protein precipitate. Addition to whole blood caused hemagglutination in the human, dog, cat, and rat. 3. The addition of salmine sulfate to whole blood perfusing isolated organs caused cessation of flow. Addition of comparable amounts to Ringer's fluid and serum perfusing organs was without effect upon the rate of Mow. 4. These experiments suggest the possibility that protamines exert toxic effects through embolic vascular phenomena.
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