Intravenous and Subcutaneous Administration of Alkali-Treated Bovine Serum Albumin to Man and Lower Animals

Abstract

Summary and Conclusion

Alkali-treated bovine serum albumin when administered by vein or by other parenteral routes is not toxic to human beings, dogs, rabbits, guinea pigs, or mice. It possesses little or no antigenicity. It is capable of raising and maintaining the blood pressure of dogs subjected to severe hemorrhage. These facts suggest that alkali-treated bovine serum albumin may prove useful as a substitute for blood in man.