Abstract
Conclusions
1. No significant difference was observed in the length of time required by diabetic and non-diabetic rats on a thiamine-free diet to develop signs of marked deficiency (39 as compared with 41 to 45 days respectively). Following treatment with thiamine, the diabetic rats recovered as quickly as did the non-diabetic animals. 2. During the period of deprivation, the glycosuria of the diabetic rats diminished, presumably because of the lowered food intake. However, urinary sugar tended to reappear at the final stage of deficiency at the time of “polyneuritis”. Carbohydrate tolerance in both the diabetic and non-diabetic rats, as judged by glucose tolerance tests, showed little change until signs of marked deficiency appeared, when there was impairment of tolerance. 3. Following-deprivation, a thiamine intake 4 to 8 times the maintenance dosage appeared to improve carbohydrate tolerance.
Get full access to this article
View all access options for this article.