Abstract
Summary
Weanling rats receiving a diet severely deficient in choline required approximately 5 mg of choline chloride per rat daily to prevent the fatal hemorrhagic kidney disease. Choline deficiency was produced within 7 to 14 days at any time during the rapid growing period when choline was omitted from the diet. Weanling rats fed a stock diet for periods of 3 or 5 weeks were somewhat less susceptible to choline deficiency than rats fed the diet low in choline and supplemented with 20 mg of choline chloride daily for similar periods.
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