Abstract
Summary
Studies of the effect of certain media on the action of sulfonamides indicate that a medium which may seem to be inhibitory is one which favors the growth and multiplication of bacteria so that an ultimate large bacterial population results. Our data also indicate that a medium, which by comparison may seem not to be inhibitory, is one which is not favorable to the development of large numbers of the bacteria under study. It is also apparent that the type of medium, time of incubation and number of bacteria inoculated are important factors which should influence conclusions drawn from sulfonamide studies in vitro. Prolonged incubation may result in adaptation of the bacteria to unusually high concentrations of the sulfonamide.
Get full access to this article
View all access options for this article.