Abstract
Summary
1. The pressor activity of certain aromatic amines is destroyed by aeration in vitro in the presence of quinones. 2. Simultaneous injection of dihydroxyphenyl-alanine and small amounts of copper salts in hypertensive rats causes a considerable lowering of blood pressure. 3. It is suggested that tyrosinase reduces the blood pressure by its oxidative effect on acceptor substances of the catechol type such as dopa and epinephrine, which in turn, upon oxidation to ortho-quinones, destroy the pressor amines in vivo.
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