Inability of Purified Renin to Reduce the Blood Pressure of Hypertensive Dogs. ∗

Abstract

Discussion and Summary

The inability of prolonged administration of purified renin to change materially the blood pressure of the 3 hypertensive dogs reported herein does not necessarily refute the findings of Wakerlin, for he used a crude preparation of renin, and the reductions in pressure in his hypertensive dogs may have been due to some other factor present in his kidney extracts. The present observations indicate, however, that the prolonged administration of purified renin neither reduces the blood pressure of hypertensive dogs nor endows their plasma with the ability to inhibit the vasopressor response of renin.