Abstract
Potassium cyanide was administered to two dogs in amounts sufficient to produce severe poisoning. One animal was kept upon a uniform, analyzed diet throughout the experiment (9 days) and the other was given no food during the experiment (5 days). In both animals an increase in the total nitrogen of the urine occurred on the day of poisoning which continued during the next following day. This increase was caused mainly by an increase in the amount of urea and by slight increase in the amounts of ammonia, total creatinin (sum of creatin and creatinin) and undetermined nitrogen (purin bases, uric acid, allantoin, amino-acids etc.). Neither experiment gave indication of marked percentage increase either of ammonia or of undetermined nitrogen, for the distribution of the nitrogen remained practically normal. Well marked absolute and percentage increase of creatin, and decrease of creatinin, was observed. Creatin was eliminated by the fasting dog throughout the whole period of observation.
Increase in the total sulphur eliminated was marked on the day of poisoning but, unlike the total nitrogen, returned to normal on the following day. The neutral sulphur was increased both absolutely and relatively to total sulphur on the poison day and that following. A corresponding decrease in oxidized sulphur was observed.
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