Abstract
Summary
A modified alcoholic precipitation method is described for the preparation of non-toxic gonadotrophic concentrates from normal male urine.
Assayed in normal rats, such concentrates of pooled samples of urine of healthy college men give a quantitative titer of 1.0 to 4.5 rat units per liter. In normal mice titers of 6.0 to 20.0 mouse-uterine units per liter were obtained.
Assayed in hypophysectomized rats it is found that follicle stimulation and interstitial cell repair are usually produced at the same dosage level, although in some instances follicle stimulation may be produced at a dosage level as low as one-third that necessary for interstitial cell repair.
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