Synergism Between Thyrotropic and Growth Hormones of Pituitary. Body Weight Increase in Hypophysectomized Rat. ∗

Abstract

Summary

Purified pituitary growth hormone, when given in combination with purified pituitary thyrotropic hormone, is markedly increased in its capacity to stimulate body weight gain in the hypophysectomized rat. Since the thyrotropic preparation, given alone at the same dose level, is almost free of intrinsic growth-promoting potency, this action must be considered more than additive, and would appear to constitute a true synergistic effect.