Abstract
Summary
Inhibition tests using varying numbers of pneumococci in varying concentrations of sulfapyridine and sulfathiazole indicated that except for highly resistant strains, there is a straight line relationship between the amount of drug required to inhibit growth and the number of pneumococci inoculated up to about 100,000. Larger inocula were not inhibited regardless of the amount of drug present. A method is described whereby this quantitative relationship may be applied to testing the sulfonamide susceptibility of pneumococci and expressing the results in terms of the concentration of sulfonamide required to inhibit the growth of a given number of bacteria.
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