Abstract
Summary
We have been able to confirm the observations of Croxatto and Croxatto that commercial pepsin at pH 2.0 reacts with renin-activator to form a substance similar to and probably identical with angiotonin. Furthermore, we found crystalline pepsin active. The reaction proceeds satisfactorily at pH 2.0 but is halted at pH 6.5 in sharp contrast to that between renin and renin-activator. At pH 6.5 to 7.0 the latter reaction yields angiotonin abundantly but none is formed at pH 2.0 to 4.0.
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