Abstract
Discussion and Summary
This report deals with an agglutinating reaction of staphylococcal toxin for rabbit leucocytes. When this test is carried out carefully, the results are clear-cut and remarkably consistent. Except for the fact that the leucocytic suspension is more exacting than a red cell suspension to prepare, the test is as easily and quickly set up and read as a test for bacterial hemolysin.
Our experiments demonstrate that there is a definite correlation between the content of leuco-agglutinin and the content of leucocidin in any toxin, also that both activities are destroyed at the same temperature.
If we are correct in the interpretation of our results, leuco-agglutinin and leucocidin actually represent two stages of the action of the same toxic substance, and the leuco-agglutinin test, because of its simplicity and its clear-cut quantitative results, may be used to advantage over previous methods for the quantitative determination of leucocidin in staphylococcal toxins.
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