Abstract
Summary
1. The acute toxicity of ouabain, cymarin, and coumingine hydrochloride has been compared by subcutaneous injection in cats, rabbits, guinea pigs, rats, and mice. 2. Both mice and rats are much more tolerant to ouabain and cymarin than cats in the ratios of 62:1 to 671:1. Regarding the alkaloid, coumingine HCI, which also has a digitalis-like action, their resistance is not so marked, being in the ratios of 13:1 to 29:1. 3. Guinea pigs and rabbits, like cats, are highly susceptible to ouabain, cymarin, and coumingine HCI.
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