Abstract
Summary and Conclusion
Following intraperitoneal inoculation of small doses of sarcoma S 37, 89 of 101 males (88%) developed tumors, as compared with 65 of 110 females (59%). This difference in resistance between males and females was completely abolished by larger doses of sarcoma, which produced tumors in 102 of 108 males (94%) and in 108 of 114 females (95%).
Tumors produced by intraperitoneal inoculation of sarcoma were uniformly fatal and in no instance was spontaneous regression of such a tumor observed.
Comparison of these results with those obtained by intradermal inoculations of sarcoma S 37 1 suggests that careful dosage of the tumor-cell suspension and the route of inoculation are most important in demonstrating the influence of sex on resistance to transplantable neoplasms. Neither of these factors has been stressed sufficiently, heretofore, in studies on the evolution of implanted tumors in different sexes.
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