Abstract
Summary
Target cells (abnormally thin erythrocytes) appeared in considerable numbers following splenectomy in dogs and guinea pigs and complete ligation of the splenic veins in dogs. In rabbits, splenectomy failed to result in the development of target cells. The spleen either has a direct effect on the red cells passing through it or a hormonal effect on the last stages of erythroblastic maturation in the bone-marrow.
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