Abstract
Conclusions
Bovine serum, bovine plasma, and bovine serum globulin are very toxic when given by the intravenous route to dogs. The toxicity of the whole serum or plasma appears to be due to the serum globulin or related protein fractions. The intravenous administration of bovine serum albumin is not only harmless, but is effective in raising and maintaining the blood pressure of dogs subjected to severe hemorrhage. Since bovine blood is readily available, bovine serum albumin may prove useful as a substitute for blood. A study of the effects of the intravenous administration of bovine serum albumin in human beings will be reported later.
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