Abstract
Summary
2-sulfanilamido-5,6,7,8-tetrahydroquinazoline (I), 2-sulfanilamido-4,5-dimethyl pyrimidine (II), 2-sulfanilamido-bornylene pyrimidine (III), 2-sulfanilamido-4-n-hexylpyrimidine (IV), 2-sulfanilamido-5,6,7,8-tetrahydro-8-isopropyl-5-methyl quinazoline (V) and 2-sulfanilamido-4,6-dimethyl pyrimidine (VI) were tested for chemotherapeutic activity in mice infected with strain C-203 of β-hemolytik streptococcus. Compounds III, IV and V were inactive and I exhibited only a slight protective action. A definite prolongation of survival time was caused by II and VI, however, neither of these appeared worthy of extended study because II failed to afford complete protection during therapy and VI exhibited a relatively high acute oral toxicity in mice.
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