Abstract
Summary
1. Lesions of the anterior hypothalamic area and preoptic region were associated with a definite and apparently isolated rise in blood urea, no change being noted in the level of the other blood substances tested. 2. In 3 animals surviving beyond 18 days the elevated blood urea returned to a normal level (Table I). 3. With one exception the kidneys of the operated animals were macroscopically normal. 4. No apparent interdependence was discerned between the level of blood urea and the state of severe anemia or between the former and body temperature or the development of obesity. The disturbance in the level of blood urea presumably is not associated with any discernible metabolic disorder.
The rise in blood urea may be due to an impairment of the ability of the kidney to clear urea at normal blood level; an increased blood urea may be a prerequisite for the adequate elimination of this substance when lesions are made in the anterior hypothalamic and preoptic regions.
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