Abstract
Summary
The rate of absorption of free estradiol, and dipropionate and caprylate of estradiol from subcutaneously implanted tablets has been studied in the guinea pig. The average percentage absorption per day was very similar to that found by Emmens in the rat. Average percentage absorption from 17-caprylate tablets was 3 times less than that from tablets of free estradiol. On the contrary, average percentage of absorption from dipropionate tablets was greater than from estradiol tablets. Combination of estradiol with two molecules of propionic acid so greatly enhanced the percentage absorption in the guinea pig that the number of molecules of estradiol available from one square millimeter of a dipropionate tablet became similar to that available from one square millimeter of a tablet of the free hormone.
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